Phenyl-substituted dihydropyrazines with DNA strand-breakage activity.
نویسندگان
چکیده
Monophenyl-substituted dihydropyrazines (Ph-DHP-1 to 4) of 2,3-dihydro-5,6-dimethylpyrazine (Me-DHP-1), which have the inductive effects of apoptosis and mutagenesis, were synthesized and their biological effect was investigated in terms of DNA strand-breakage. Differences between the phenyl- and methyl-substituted dihydropyrazines were examined.
منابع مشابه
Biol. Pharm. Bull. 30(9) 1663—1667 (2007)
of dihydropyrazines (DHPs) such as 2,3-dihydro-5,6-dimethylpyrazine (Me-DHP), which causes DNA strand breakage in the plasmid pBR322. We showed that DHPs inhibit growth and cause mutagenesis in Escherichia coli and that Me-DHP is cytotoxic and genotoxic in E. coli due to the production of radical species in the presence of Cu . Phenyl substituted dihydropyrazines (Ph-DHPs) have much higher DNA ...
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ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 58 6 شماره
صفحات -
تاریخ انتشار 2010